Wet-spun bi-component alginate based hydrogel fibers: Development and in-vitro evaluation as a potential moist wound care dressing

In this study, bi-component alginate-hyaluronic acid (AHA) fibers were developed by using two different routes. the first method, sodium alginate dope solution was extruded into a coagulation bath containing CaCl2 and subsequently dip-coated with hyaluronic (HA) whereas, in second acid-containing directly bath. The resulting AHA then dehydrated 25–100% v/v acetone solutions dried air. characterized surface morphology, physicochemical analysis, mechanical performance, swelling percentage, total liquid absorption (g/g), cell viability, release behavior. results showed that produced method have better high absorption, percentage more controlled of acid. biocompatibility toward nHDF line in-vitro testing, MVTR values (650–800 g/m2/day) are suitable range for maintaining moist wound proving to be appropriate promoting healing.